yr12student22

yr12student22 In a silent mutation theres no change to the protein’s 3D tertiary structure as the single base substitution still codes for the same amino acid due to the degeneracy of the genetic code.
With missense although there’s a change of one amino acid- it does not entirely change the 3D tertiary protein structure due to misfolding as a result of different interactions between the variable R groups of amino acids in the polypeptide chain. This wont be as significant of an effect compared to framshifts where the protein becomes non functional