what is the structure of monoclonal antibodies?
biology unit 3/4
what's the relationship between innate and inflammatory response?
- Edited
do naive t cells or cytotoxic t cells undergo clonal expansion?
atarwonders they consist of one big polypeptide (heavy chain) and one small polypeptide (light chain). They also have specific variable regions, which are complementary to the antigen. (the same as a normal antibody)
- Edited
atarwonders you only need to talk about whether the Indigenous populations were able to develop immunity as well as the British (hint: British developed immunity at a younger age and thus already had antibodies, and Indigenous Australians were exposed to it for the first time)
atarwonders Hi there! For this question the main point is about prior immunity so for 3 marks Iβd say :β
- The British population had been frequently exposed to the small pox virus before, whereas indigenous Australians were exposed to the small pox virus for the first time upon European arrival
- Hence the indigenous Australians did not have any prior natural active immunity, and did not produce antibodies and memory cells against the small pox virus unlike the British
- This caused the indigenous Australians to be more likely to experience severe symptoms of the viral infection causing a much greater number of deaths and infection cases than the British population
(Make sure you use comparative statements here because itβs about the immunity of indigenous Australians VS the British population)hope this helps!
chemistry1111 Naive T cells undergo clonal expansion and selection to form cytotoxic T cells or memory T cells
What is the underlying difference between a rule based approach and consequences based approach?
Example would really be nice
spicynuggets
Consequences-based approach = Aims to maximise the positive outcomes while minimising the negative outcomes.
- Suggests that individuals should be driven by consideration for the consequences that are likely to result.
- Often emphasises the surrounding circumstances of an action, and may sometimes allow an individual to break the rules in order to achieve the greatest good for the greatest number of stakeholders.
Duty/rule-based approach = Promotes the responsibility of the agent above all else, and places importance on the duty of each individual.
- Suggests that individuals should be driven by a fundamental duty to act in a certain way.
- Aim is to follow set rules and responsibilities, with less regard for the consequences that may result.
Is rational drug design in the new study design?
Could someone please explain the function of the PAM sequence?
biology nope. That was from the last study design, so you can ignore these questions!
biology ok. So, the PAM sequence is a sequence of nucleotides called the protospacer adjacent motif (usually NNG, with N being any nucleotide). Viral DNA has many PAM sequences. When the protospacer is cut out of the viral DNA that has been injected into the bacteria, this is done a little after the PAM site by Cas1 and Cas2 (just other restriction endonucleases). The purpose of the PAM site is for the Cas9 cutting part of the CRISPR-Cas9 process. When the Cas9 enzymes identifies viral DNA and a PAM region on it, it opens up the DNA and sees whether or not the gRNA is complementary to the sequence of bases upstream from the PAM sequence but on the opposite strand. If the gRNA is complementary to the viral DNA section after the PAM sequence, it will cut the DNA on both strands just upstream from the PAM. However, if the gRNA does not match the viral sequence, Cas9 closes the viral DNA and continues to search for another PAM site (it can take multiple goes to find the right one since there are lots of PAM sites). So in summary, the PAM site is like a recognition tool or tag for Cas9 to search for and identify, allowing it to check the viral DNA with the gRNA before making a cut. Hope that makes sense!
- Edited
what is the difference between social implication and biological implication? and also do we need to include that in sympatric speciation gene flow doesnt occur
_sophiestudies_ Thankyou so much!
for photosynthesis do you say the light dependent stage is the grana or thylakoid?
what is the role of rubisco?
clazah a granum is a stack of thylakoids, so u can say either i think
does anyone have access education biology exam
Is it okay to write exam in pencil