- Edited
Humoral response:
- Antigen-presenting cells (i.e. macrophages and dendritic cells) phagocytose pathogens and present its antigens on their MHC II markers. They are then transported to secondary lymphoid tissue.
- The antigens are presented to naïve B cells with corresponding B cell receptors (antibodies). They phagocytose them and present them on their MHC II markers. This causes them to become activated/selected.
- They present the antigens to T helper cells, which bind using their specific T cell receptors. This causes them to become activated/selected.
- T helper cells release cytokines, which stimulate the selected B cell to undergo clonal expansion (proliferate/produce many of itself) and differentiate to form plasma B cells and memory B cells.
- Plasma B cells produce antibodies, which can then be sent to the area of infection to opsonise, agglutinate, naturalise, and/or activate complement proteins.
- Memory B cells provide long-lasting immunological memory, activated when they come in contact with the pathogen again. The rapidly proliferate to form memory plasma B cells that produce larger amounts of antibodies, and more memory cells to strengthen this immunological memory.