chimichurri I agree with prettypink1881, but also, during a viral infection, usually both your cell-mediated and humoral responses occur. Cell-mediated response targets infected cells, but the humoral response will also be initiated because the cells lyse and release more viral particles into the extracellular environment. Viruses can be extracellular and intracellular, so both responses would be initiated. With a vaccines, both would be usually be stimulated, as mentioned in the answer by VCAA (they state that B and T memory cells are produced). A live attenuated virus in the vaccine will replicate using the person's cells but at a very low level (not enough to cause proper disease), meaning a cell-mediated response is necessary. However, some of virus won't be inside cells and will be in the blood, requiring the humoral response. Both responses almost always work together in the third line of defence (since almost all pathogens will be able to be extracellular and intracellular in some way, and there a exceptions to these processes anyway since biology is kinda like that ahaha).